Endocrine Abstracts

Background: Leptin is a multi-functional hormone of which low levels are associated with immuno-deficiency. We and others have shown that leptin promotes secretion of inflammatory cytokines (TNF-alpha and IL-6) by monocytes (1) and activated lymphocytes (2). The leptin receptor (Ob-R) is expressed on neutrophils and leptin enhances oxidative species production by stimulated neutrophils.Aim: To access whether CD11b expression on human neutrophils is a di...